PL EN


Preferences help
enabled [disable] Abstract
Number of results
2006 | 66 | 4 | 311-319
Article title

Behavioral evaluation of ischemic damage to CA1 hippocampal neurons: Effects of preconditioning

Selected contents from this journal
Title variants
Languages of publication
EN
Abstracts
EN
In Mongolian gerbils, global forebrain ischemia induces enhanced locomotor activity and the disruption of nest building immediately after the insult, followed by damage to hippocampal neurons developing 3 days later. Preconditioning by a brief episode of sublethal ischemia induces the protection of CA1 hippocampal neurons against a lethal ischemic insult. We examined how preconditioning with 2-min ischemia affects disturbances in the nest building behavior and locomotor activity induced by the injurious 3-min ischemia. Morphological examination confirmed that preconditioning significantly reduced neuronal damage in CA1 evoked by injurious ischemia. Behavioral studies demonstrated that preconditioning reduced the locomotor hyperactivity and latency in nest building after test ischemia, in comparison to sham or naive animals. The results indicate that the nest building test and measurement of locomotor activity may be used for an early in vivo prediction of the extent of ischemic brain damage and tolerance induced by ischemic preconditioning.
Keywords
Publisher

Year
Volume
66
Issue
4
Pages
311-319
Physical description
Contributors
References
Document Type
ARTICLE
Publication order reference
Jerzy W. Lazarewicz, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St, 02-106 Warsaw, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-3dc6a6b2-e0cb-3b0e-9111-300c8c8edd7e
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.