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1993 | 45 | 1 | 31-41
Article title

Psychotropic effects of angiotensin II N-terminal fragments in rats

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EN
Abstracts
EN
In this study the effects of angiotensin (AII) angiotensin II hexapeptide [AII(1-6)] and angiotensin II pentapeptide [AII(2-6)] on the motility, stereotypy, learning of conditioned avoidance responses (CARs) and recall of a passive behavior making it possible to avoid averisve stimulation in rats, were compared. All the peptides were injected into the lateral cerebral ventrice (icv) in a dose of 1nmol. AII caused a statistically significant increase in the number of crossings, rearings, and bar approaches in an open field whereas [AII(1-6)] and [AII(2-6)] were inactive in this test. The stereotypic behavior induced by an intraperitoneal (ip) injection of apomorphine (1mg/kg) and amphetamine (7,5 mg/kg) was statistically significantly enhanced only in the rats wihich received AII icv. The application of AII, but not that of [AII(1-6)] and [AII(2-6)] resulted in a quicker acquisition of the CARs. A better recall of passive avoidance was achieved only by AII, while the fragments [AII(1-6)] and [AII(2-6)] had no effect. These findings indicate that the 1-6 and 2-6 fragments of AII do not possess a psychotropic activity like that of the parent ictapeptide.
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45
Issue
1
Pages
31-41
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article
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YADDA identifier
bwmeta1.element.element-from-psjc-3da7d375-0911-31ef-a40f-fd9f6937bb46
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