DNA viruses and genetic modification of dendritic cells

• Authors: L. Jenne , A. Steinkasserer
• Languages of publication: EN

Abstracts

EN

An alternative approach to the use of tumor-peptide-loaded dendritic cells (DC) in immunotherapy would be the use of genetically modified DC using viral vectors expressing tumor-associated antigens (TAA). However, viruses have developed several immune escape mechanisms and, thus, one has to study the interaction between viruses and DC before these viruses can be used as an alternative strategy. Here we report that vaccinia virus (VV) as well as herpes simplex virus type-1 (HSV-1) are able to potently infect monocyte-derived DC, however, this infection leads to the inhibition of the DC-mediated T cell stimulation in vitro.

Keywords

EN

DENDRITIC CELL; GENE THERAPY; HERPES VIRUS; VACCINIA VIRUS

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 4
• Pages: 273-279

Contributors

author

L. Jenne

author

A. Steinkasserer

• Document Type: REVIEW
• Publication order reference: L. Jenne, Department of Dermatology, University of Erlangen-N?rnberg, Hartmannstra?e 14, D-91052 Erlangen, Germany