Oligonucleotides as potential therapeutic tools against hepatitis C virus

• Authors: A. Swiatkowska , J. Ciesiolka
• Languages of publication: EN

Abstracts

EN

Hepatitis C virus belongs to the group of particularly dangerous and most extensively studied RNA viruses. Since no vaccine for HCV is known and post-exposure treatment of infected patients has not been yet optimal, novel therapeutic strategies are being developed very intensively. Oligonucleotide-based molecular tools such as antisense oligonucleotides, ribozymes, DNAzymes, aptamers and interfering RNAs are proving as effective modulators of gene expression and potential therapeutics. Several examples of oligonucleotide-based molecular tools directed towards HCV viral RNA are discussed in this review.

Keywords

EN

APTAMER; HEPATITIS C VIRUS; OLIGONUCLEOTIDE THERAPY; RIBOZYME

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2010
• Issue: 1
• Pages: 13-33

Contributors

author

A. Swiatkowska

author

J. Ciesiolka

• Document Type: REVIEW
• Publication order reference: Agata Swiatkowska, Pracownia Biochemii RNA, Instytut Chemii Bioorganicznej, Polska Akademia Nauk, ul. Noskowskiego 12/14, Poznan, Poland