Oligonucleotides as potential therapeutic tools against hepatitis C virus
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Hepatitis C virus belongs to the group of particularly dangerous and most extensively studied RNA viruses. Since no vaccine for HCV is known and post-exposure treatment of infected patients has not been yet optimal, novel therapeutic strategies are being developed very intensively. Oligonucleotide-based molecular tools such as antisense oligonucleotides, ribozymes, DNAzymes, aptamers and interfering RNAs are proving as effective modulators of gene expression and potential therapeutics. Several examples of oligonucleotide-based molecular tools directed towards HCV viral RNA are discussed in this review.
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Agata Swiatkowska, Pracownia Biochemii RNA, Instytut Chemii Bioorganicznej, Polska Akademia Nauk, ul. Noskowskiego 12/14, Poznan, Poland