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2000 | 48 | 5 | 473-480
Article title

Prostaglandins and inflammation: The cyclooxygenase controversy

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EN
Abstracts
EN
Prostaglandins (PGs) are arachidonic acid metabolites produced by the action of the enzyme cyclooxygenase (COX). Although PGs are important mediators of inflammation in various diseases, they also are key factors in the physiological regulation of gastrointestinal and renal homeostasis. The finding that two distinct COX isoforms are responsible for PG synthesis has provided basis to the opposite actions of PGs in inflammation and homeostasis regulation. COX-1-derived PGs are thought to mediate cytoprotective actions on the gastrointestinal mucosa, whereas COX-2-derived PGs are assumed to display pro-inflammatory properties. This dichotomy has led to the development of selective inhibitors of COX-2 activity which are safer for the gastrointestinal mucosa than the classic inhibitors of both COX isoforms. However, some COX-2 antiinflammatory properties have been recently demonstrated in several experimental models of inflammation. These studies have raised some concern about the potential adverse effects of COX-2 selective inhibitors. In addition, there is evidence that COX-1 displays pro-inflammatory properties, depending on the organ and on the stage of the inflammatory response. This review will focus on the roles of COX-1 and COX-2 in inflammation, based on studies involving pharmacologic COX inhibitors as well as COX knockout mice, with a particular emphasis on the gastrointestinal tract
Publisher

Year
Volume
48
Issue
5
Pages
473-480
Physical description
Contributors
author
References
Document Type
REVIEW
Publication order reference
O. Morteau, Department of Pulmonary Medicine, Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
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bwmeta1.element.element-from-psjc-3bad70bc-668f-3e91-9cbc-c6308428a27a
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