ApoE polymorphism in Polish patients with Alzheimer's disease

• Authors: M. Lalowski , K. Czyzewski , A. Pfeffer , M. Barcikowska , H.l Kwiecinski
• Languages of publication: EN

Abstracts

EN

Alzheimer's disease is a genetically heterogeneous disorder of CNS. The presence of APOE-epsilon4 allele is known to increase the risk of early and late onset sporadic and late onset familial forms of AD. In various Western European countries, USA, Canada, Japan and Australia the allelic frequency ranges between 0.1- 0.18 in controls, and between 0.24- 0.52 in AD patients. In the present study on Polish population, we analyzed the frequency of APOE-epsilon4 allele in persons with Alzheimer's disease (AD). APOE genotypes were determined in 30 mild to moderate AD (83%) and mixed dementia (MIX, 17%), as well as in 11 nondemented first- degree relatives of AD (NDR), recruited from AD patient registry in Warsaw. Among the AD and MIX patients the APOEepsilon4, epsilon3,epsilon2 allele frequency was 0.333, 0.65 and 0.017 respectively.

Keywords

EN

ALZHEIMER DISEASE; APOLIPOPROTEIN; POLYMORPHISM

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1998
• Volume: 58
• Issue: 1
• Pages: 65-68

Contributors

author

M. Lalowski

author

K. Czyzewski

author

A. Pfeffer

author

M. Barcikowska

author

H.l Kwiecinski

• Document Type: article
• Publication order reference: M.M.Lalowski, Department of Cellular Signaling Medical Research Centre, Polish Academy of Science, 5 Pawinski St., 02-106 Warsaw, Poland, Email: [e-mail]