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2001 | 49 | 2 suppl. | 61-64
Article title

Is tumor expression of the major histocompatibility complex antigen required for T cell immune surveillance?

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EN
Abstracts
EN
Tumor expression of major histocompatibility complex antigen (MHC) class I and class II is not essential for the induction of memory T cells. However, induction of MHC class I-restricted effector cytotoxic T cells (CTL) appears dependent on MHC class I expression on tumors. Moreover, the effector function of tumor-specific CTL requires direct recognition of the tumor. In contrast, both the inductive and the effector phases of MHC class II-restricted T cells are independent of MHC class II expression on tumors.
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author
References
Document Type
REVIEW
Publication order reference
Y. Liu, Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
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YADDA identifier
bwmeta1.element.element-from-psjc-3a7de673-3f51-38ed-a380-2925690d8e54
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