Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2003 | 51 | 1-2 | 117-123

Article title

Effect of capsaicin and dimethyl sulphoxide (DMSO) on ion transport in isolated skin of frog (Rana esculenta L.)

Title variants

Languages of publication



The effects of capsaicin, dimethyl sulphoxide and pH changes on transport of sodium and/or chlorine ions in an isolated frog skin, were studied using electrophysiological methods, adapted to evaluation of ionic currents occurring in the epithelial tissues and organs. The experiment consisted in measuring potential difference (PD in mV) of an isolated skin of the aquatic frog, Rana esculenta L., placed in a Ussing apparatus. The ionic transport processes were modified through incubation of the tissue in Ringer solution and in Ringer solution supplemented with amiloride, bumetanide, and also with dimethyl sulphoxide. The direct effect of capsaicin and dimethyl sulphoxide (DMSO) on frog skin was assessed while these compounds were added to the Ussing chamber with a pipette and a peristaltic pump. Adaptive reactions of the tissue were assessed following at least 60-min exposure to those compounds. It has been demonstrated that amiloride-inhibited sodium ion transport and acidification of the incubation medium (pH 6.4) inhibited mechanically induced epithelium reactions. Both compounds, capsaicin and DMSO modified ionic transport processes depending on the mechanical stimulation.



Document Type


Publication order reference

D.I. Kosik-Bogacka, Department of Biology and Medical Parasitology, Pomeranian Academy of Medicine, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.