Alternations of GABAb binding caused by acute and chronic lead administration

• Authors: J. Waskiewicz
• Languages of publication: EN

Abstracts

EN

The effect of lead on GABA(b) binding was studied on membranes obtainded from acute and chronically lead-treated rats. Acute lead treatment reduced both GABA(b) affinity (K(d)) by about 30% and density of receptor (B(max)) by about 15%. On the contrary chronic lead treatment increased receptor capacity by about 20% in spite of decreased receptor affinity by 25%. Both acute and chronic lead treatment shiffted displacement curves toward higher concentration of non-labelled compound (decreased affinity). The results show that lead can affect the GABA(b) binding in two ways: by reducing affinity of binding and by altering capacity of binding.

Keywords

EN

GABA; GAMMA-AMINOBUTYRIC ACID; RECEPTOR AFFINITY; RECEPTOR DENSITY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1996
• Volume: 56
• Issue: 1
• Pages: 227-231

Contributors

author

J. Waskiewicz

• Document Type: proceeding
• Publication order reference: J.Waskiewicz