Molecular mechanisms regulating transport of low molecular substances in hepatocyte

• Authors: K. Zwierz , P. Wielgat , M. Borzym-Kluczyk
• Languages of publication: PL

Abstracts

EN

Transporters of sinusoidal and lateral membranes mediate uptake of inorganic and organic substances to hepatocyte. In hepatocyte lipophilic compounds are biotransformed (hydroxylated and conjugated) and excreted into bile and urine. Vectorial movement of solutes and water from blood to bile is maintained by pumps of ABC superfamily secreting bile salts (bile acid dependent flow) and other solutes: bilirubin, phospholipids, glutathione and inorganic salts (bile acid independent flow).

Keywords

EN

BILE; BILIRUBIN; HEPATOCYTE; LIVER; PHOSPHOLIPID

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2003
• Volume: 57
• Issue: 1
• Pages: 91-116

Contributors

author

K. Zwierz

author

P. Wielgat

author

M. Borzym-Kluczyk

• Document Type: ARTICLE
• Publication order reference: K. Zwierz, Zaklad Biochemii Farmaceutycznej AM, ul. Mickiewicza 2, 15-230 Bialystok, Poland