Cytolisins and homologous proteins produced by Gram-negative bacteria. I. Hemolysis and leukotoxins of Escherichia coli, Bordatella pertusis, Pasteurella haemolytica and Actinobacillus sp.
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Cytolysins produced by Gram-negative bacteria belong to the pore forming bacterial proteins. A branch of these toxins represents RTX family of proteins. The RTX (repeats in toxin) family name has been proposed based on the common presence of tandem copies of a nine-amino acid repeat (L-X-G-G-X-G-(N/D)-D-X). The paper presents the genetics, synthesis, secretion and cytolytic activity of these toxins.
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A.Rozalski, Instytut Mikrobiologii i Immunologii Uniwersytetu Lodzkiego, ul. Banacha 12/16, 90-237 Lodz, Poland