Age-related fragmentation of mitochondrial DNA associated with oxygen damage

• Authors: T. Ozawa
• Languages of publication: EN

Abstracts

EN

In the patients with mitochondrial cardiomyopathy, fragmentation and oxidative damage in mtDNA was documented at their age 7 to 19 equivalent to the normal subjects of age over 80.Exposure of a cultured cell line under oxygen stress, 95% oxygen, cold mimic these changes in mtDNA 1within 3 days leading as apoptotic cell death, whereas mtDNA lacking cells are relatively immune.These facts support the 'redox mechanism of agening'.

Keywords

EN

FRAGMENTATION; MITOCHONDRIAL DNA; OXYGEN DAMAGE

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 1996
• Issue: 4
• Pages: 208-222

Contributors

author

T. Ozawa

• Document Type: article
• Publication order reference: Takayuki Ozawa, Dept. of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, 65 Tsuruma-cho, Showa0ku, Nagoya 466, Japan