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Journal
1996 | 4 | 208-222
Article title

Age-related fragmentation of mitochondrial DNA associated with oxygen damage

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EN
Abstracts
EN
In the patients with mitochondrial cardiomyopathy, fragmentation and oxidative damage in mtDNA was documented at their age 7 to 19 equivalent to the normal subjects of age over 80.Exposure of a cultured cell line under oxygen stress, 95% oxygen, cold mimic these changes in mtDNA 1within 3 days leading as apoptotic cell death, whereas mtDNA lacking cells are relatively immune.These facts support the 'redox mechanism of agening'.
Journal
Year
Issue
4
Pages
208-222
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References
Document Type
article
Publication order reference
Takayuki Ozawa, Dept. of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, 65 Tsuruma-cho, Showa0ku, Nagoya 466, Japan
YADDA identifier
bwmeta1.element.element-from-psjc-329191a0-2eee-37d4-970c-6550016de5dd
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