Prenatal exposure to anticonvulsant drugs and spatial ability in adulthood

• Authors: A. Dessens , P. Cohen-Kettenis , G. Mellenbergh , N. van_den_Poll , J. Koppe , K. Boer
• Languages of publication: EN

Abstracts

EN

By disturbing steroid hormone balances in the fetus, the anticonvulsant drugs phenobarbital and phenytoin may affect certain aspects of cognitive functioning. In order to test this hypothesis, we studied hormone related cognitive functioning in 72 men and 75 women who had been prenatally exposed to these drugs and equal numbers of matched control subjects. The groups did not differ on word fluency, dichotic listening and a Water Level Test. On Card Rotations, however, anticonvulsant-exposed males and females obtained significantly lower scores than control subjects. These results suggest that in both males and females prenatal exposure to phenobarbital and phenytoin may affect holistic spatial processing.

Keywords

EN

ANTICONVULSANT; SPATIAL PROCESSING; STEROID

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1998
• Volume: 58
• Issue: 3
• Pages: 221-225

Contributors

author

A. Dessens

author

P. Cohen-Kettenis

author

G. Mellenbergh

author

N. van_den_Poll

author

J. Koppe

author

K. Boer

• Document Type: short communica
• Publication order reference: A. DEssens, Delta Psychiatric Hospital, P.O. Box 800, 3170 Portugaal, The Netherlands