Transgenic mice as a tools for analysis of neoplastic transformation of T and B lymphocytes

• Authors: M. Kobzdej , L. Strzadala
• Languages of publication: PL

Abstracts

EN

This article describes the significance of the mouse transgenic model in elucidation of the role and the oncogenic potential of such genes as N-ras, pim-1, bcl-2, myc and p53. The role of gene targetting by homologous recombination in the study of preneoplastic state in the mice model was also discussed.

Keywords

EN

KNOCKOUT MICE   LEUKOMOGENESIS   ONCOGENE   TRANSGENIC MOUSE  

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1996
• Volume: 50
• Issue: 2
• Pages: 113-129
• Document Type: article
• Publication order reference: M.Kobzdej, Instytut Immunologii i Terapii Doswiadczalnej PAN, ul. Weigla 12, 53-114 Wroclaw, Poland