Current status and future perspectives of DNA vaccine delivery by attenuated intracellular bacteria

• Authors: G. Dietrich
• Languages of publication: EN

Abstracts

EN

Vaccination by intradermal or intramuscular injection of antigen-encoding plasmid-DNA elicits strong cellular and humoral immune responses. Professional antigen presenting cells (APC) seem to induce these responses, making it, therefore, desirable to deliver the plasmid molecules directly to these cells. The exploitation of attenuated intracellular bacteria as DNA delivery vehicles makes the direct targeting of DNA vaccine vectors to professional APC feasible.

Keywords

EN

DELIVERY; DNA VACCINE; INTRACELLULAR BACTERIA

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 3
• Pages: 177-182

Contributors

author

G. Dietrich

• Document Type: REVIEW
• Publication order reference: G. Dietrich, Chiron Behring GmbH & Co, Preclinical Research Vaccines, D-35006 Marburg, Germany