Mesenchymal stromal cells: tissue engineers and immune response modulators

• Authors: den_ Berk L.C.J. van_ , C.G. Figdor , R. Torensma
• Languages of publication: EN

Abstracts

EN

Mesenchymal stromal cells (MSCs) show significant immune-suppressive properties both in vitro and in vivo. Based on their immune-stealth properties, allogeneic MSCs are used to treat several diseases, for example the injection of MSCs in infarcted heart tissue or their use in bone-cartilage regeneration. The most spectacular treatment was recently described. MSCs were able to down-regulate the severity of graft-versus-host disease, leading to an impressive 20 to 50% increase in the two-year survival of bone marrow transplantation patients. Here the current literature is reviewed to elucidate the different mechanisms involved in these two clinical treatment modalities of MSCs.

Keywords

EN

IMMUNOMODULATION; MATURATION; MESENCHYMAL STROMAL CELL; PROLIFERATION; T CELL; TRANSPLANTATION

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2008
• Volume: 56
• Issue: 5
• Pages: 325-329

Contributors

author

den_ Berk L.C.J. van_

author

C.G. Figdor

author

R. Torensma

• Document Type: REVIEW
• Publication order reference: Ruurd Torensma, Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Nijmegen, the Netherlands