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2008 | 56 | 5 | 325-329
Article title

Mesenchymal stromal cells: tissue engineers and immune response modulators

Content
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EN
Abstracts
EN
Mesenchymal stromal cells (MSCs) show significant immune-suppressive properties both in vitro and in vivo. Based on their immune-stealth properties, allogeneic MSCs are used to treat several diseases, for example the injection of MSCs in infarcted heart tissue or their use in bone-cartilage regeneration. The most spectacular treatment was recently described. MSCs were able to down-regulate the severity of graft-versus-host disease, leading to an impressive 20 to 50% increase in the two-year survival of bone marrow transplantation patients. Here the current literature is reviewed to elucidate the different mechanisms involved in these two clinical treatment modalities of MSCs.
References
Document Type
REVIEW
Publication order reference
Ruurd Torensma, Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Nijmegen, the Netherlands
YADDA identifier
bwmeta1.element.element-from-psjc-2a2f37b4-57e8-323b-99a8-8189cd851f1e
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