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2006 | 54 | 2 | 75-84
Article title

P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

Authors
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Languages of publication
EN
Abstracts
EN
Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly for cytokine and chemoattractant-induced 2-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers.
Publisher

Year
Volume
54
Issue
2
Pages
75-84
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
Jian-Guo Geng, Vascular Biology Center and Division of Hematology, Oncology and Transplantation, University of Minnesota Medical School, MMC 480, 420 Delaware Street S.E., Minneapolis, MN 55455, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-29daf4fd-3fa7-372a-8257-8e5bbb271af6
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