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2003 | 51 | 4 | 219-226
Article title

PPAR ? an important regulator of monocyte/macrophage function

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Languages of publication
EN
Abstracts
EN
Regulation of monocyte/macrophage function is important to coordinate immune responses. Their contact with invading pathogens activates signaling pathways that provoke pro-inflammatory gene expression and thus causing a locally restricted inflammation. Recently, the peroxisome proliferator activated receptor (PPAR) has been identified to antagonize pro-inflammatory responses in monocytes/macrophages causing an anti-inflammatory and/or desensitized phenotype to predominate. For PPAR general mechanisms in facilitating the transition from a pro- to an anti-inflammatory phenotype have been elucidated. PPAR is a member of the nuclear receptor superfamily and activated upon endogenous as well as exogenous agonist binding. Here we focus on its role in monocyte/macrophage biology in affecting inflammation. Summarizing current information, a model is proposed, giving rise to potential new therapeutic possibilities for the treatment of diseases presumably involving PPAR-dependent regulatory circuits.
Keywords
Publisher

Year
Volume
51
Issue
4
Pages
219-226
Physical description
Contributors
author
References
Document Type
REVIEW
Publication order reference
von Knethen A., Department of Cell Biology, University of Kaiserslautern, Kaiserslautern, Germany
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-29a8d4c4-6ab4-33da-b8fd-9235918e1734
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