Influence of aging on the protein profile of myelin isolated from human brain white matter

• Authors: Irena Niebroj-Dobosz , Janina Rafalowska , Miroslawa Lukasiuk , Wieslawa Wisniewska , Dorota Dziewulska
• Languages of publication: EN

Abstracts

EN

Myelin proteins composition was examined in material of 20 autoptic cases at ages from 20 to 97 years. The technique of polyacrylamide gel electrophoresis and isotachophoresis was applied. In polyacrylamide gel electrophoresis a progressive increase starting at the age of 60 years of Wolfgram protein at the expense of Folch-Less proteolipid protein and DM-20 protein was observed. The myelin-associated protein started to increase in the 4th and 5th decade of life, returning therafter to values observed in younger cases. The isotachophoretic technique did not differentiate the changes observed in myelin protein in the course of aging.

Keywords

EN

AGEING; MYELIN; PROTEIN

Discipline

• NEUROSCIENCE: NEUROSCIENCE

• Publisher: Association of Polish Neuropathologists; Medical Research Centre, Polish Academy of Sciences
• Journal: Neuropatologia Polska
• Year: 1992
• Volume: 30
• Issue: 2
• Pages: 147-154

Contributors

author

Irena Niebroj-Dobosz

author

Janina Rafalowska

author

Miroslawa Lukasiuk

author

Wieslawa Wisniewska

author

Dorota Dziewulska

• Document Type: article
• Publication order reference: Irena Niebroj-Dobosz