Leber hereditary optic neuropathy ? a disease with a known molecular basis but a mysterious mechanism of pathology

• Authors: K. Mroczek-Tonska , B. Kisiel , J. Piechota , E. Bartnik
• Languages of publication: EN

Abstracts

EN

Leber hereditary optic neuropathy is a maternally inherited type of blindness caused by degeneration of the optic nerve. It is caused by point mutations in mitochondrial DNA. Like in other mitochondrial diseases, its penetrance and inheritance is complicated by heteroplasmy, tissue distribution, and the bottleneck phenomenon in oocyte maturation. On the cellular level, the mechanism of the disease development is still mysterious. Currently three theories of pathomechanism of LHON are considered: biochemical, ROS (reactive oxygen species) and apoptotic.

Keywords

EN

LEBER HEREDITARY OPTIC NEUROPATHY; MITOCHONDRIAL DISEASE; OPTIC ATROPHY

Discipline

• GENETICS: GENETICS

• Journal: Journal of Applied Genetics
• Year: 2003
• Volume: 44
• Issue: 4
• Pages: 529-538

Contributors

author

K. Mroczek-Tonska

author

B. Kisiel

author

J. Piechota

author

E. Bartnik

• Document Type: REVIEW
• Publication order reference: E. Bartnik, Department of Genetics, University of Warsaw, ul Pawinskiego 5a, 02-106 Warszawa, Poland