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2004 | 45 | 4 | 473-476
Article title

Correlation of HLA-Cw*06 allele frequency with some clinical features of psoriasis vulgaris in the population of northern Poland

Content
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Languages of publication
EN
Abstracts
EN
Psoriasis is a common skin disease with a genetic background and significant human leukocyte antigen (HLA) associations. HLA-Cw6 is the most frequently described association, particularly with psoriasis of the early onset type. Few studies of its correlation with various psoriasis clinical phenotypes and severity of the disease have been published so far; none in the Polish population. In this study 78 patients with psoriasis vulgaris were evaluated clinically and subdivided according to the age of onset and the type of psoriasis. A system of disease severity evaluation was applied to each patient. All patients and the control group (70 unrelated persons) were typed for HLA-Cw*06. The results show that Cw*06 allele frequency was higher in psoriatics than in the control group. Our investigation confirms that the Cw*06 allele is positively associated with psoriasis vulgaris of the early onset type, with a positive family history and its more severe form.
Keywords
Year
Volume
45
Issue
4
Pages
473-476
Physical description
References
Document Type
SHORT COMMUNICA
Publication order reference
A. Szczerkowska-Dobosz, Department of Dermatology, Medical University, Debinki 7, 80-211 Gdansk, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-25f880e1-f3ed-3536-8e83-ad9b47137ef6
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