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2001 | 49 | 2 | 91-100
Article title

The receptors regulating natural cytotoxic effector functions

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EN
Abstracts
EN
Natural cytotoxic effector functions are regulated by a multitude of opposing signals provided by immunoglobulin and lectin-like functional molecules. While inhibitory receptors possess ITIM cytoplasmic sequences recruiting tyrosine phosphatases, activatory receptors require association with accessory ITAM-bearing molecules. One considerable group of natural cytotoxic cell receptors are specific for classical and non-classical class I antigens and detect both qualitative and quantitative changes in the autologous MHC-I phenotype. Non-MHC-I specific receptors provide signaling in the absence of MHC-I antigens or in response to not well-known stress-induced antigens. NK cell receptors may equally participate in the regulation of target cell functions through contact or soluble mediator-dependent mechanisms. The identification of NK cell-regulating molecules has lead to the elucidation of more general principles underlying immune homeostasis.
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REVIEW
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M. Nikolova, National Center of Infectious and Parasisitic Diseases, 1504 Sofia, Bulgaria,
YADDA identifier
bwmeta1.element.element-from-psjc-25ba3e77-25a2-3528-9810-e15ced944ff9
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