PL EN


Preferences help
enabled [disable] Abstract
Number of results
2005 | 53 | 3 | 234-244
Article title

Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system

Title variants
Languages of publication
EN
Abstracts
EN
During the last decade, research on attaching-effacing (A/E) bacteria/host cell interactions has revealed much of the molecular basis of colonization and lesion formation. The colonic mucosa represents the first line of defense against these pathogens, and its integrity is required to avoid translocation of bacteria or bacterial soluble factors into the infected host. Therefore, the cellular immune response to A/E pathogens plays an important role in bacterial pathogenesis since it can clear the bacteria or modulate the inflammatory processes. Data obtained from infected patients demonstrate a correlation between the production of pro-inflammatory cytokines and the severity of the disease. In vitro studies of infected epithelial cells have clearly elucidated A/E bacteria-induced host signal transduction events. However, the identification of the bacterial factors responsible for cellular activation remains a subject of controversy. Experimental studies with knock-out mice infected with Citrobacter rodentium, a rodent A/E pathogen, indicate that innate immunity is an essential component of pathogenesis. This review summarizes in vivo and in vitro evidence for the induction and potential role of the innate immune system during infection with A/E bacteria.
Publisher

Year
Volume
53
Issue
3
Pages
234-244
Physical description
Contributors
author
author
author
References
Document Type
REVIEW
Publication order reference
Alain P. Gobert, Unite de Microbiologie, Institut National de la Recherche Agronomique, Centre de Theix, 63122 Saint-Gencs-Champanelle, France
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-24e48bc8-41e6-3297-a742-f96257bcf661
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.