Immune balance in critically III patients

• Authors: M.R. Pinski
• Languages of publication: EN

Abstracts

EN

The systemic inflammatory response reflects the non-specific clinical expression of a profound activation of the body?s immune responsive elements. Immune activation and immune suppression coexist in the blood of patients with severe sepsis. It is their interaction and the resultant host parenchymal responses that ultimately define the course of sepsis. Importantly, neither profound immune activation (pro-inflammatory) or immune suppression (anti-inflammatory) characterize the dominant process. Rather, there is a combined low grade pro-inflammatory state associated with an immune hyporesponsiveness that defines the usual immunologic state of the patient with severe sepsis.

Keywords

EN

INFLAMMATORY MEDIATOR; INFLAMMATORY RESPONSE; LEUKOCYTE ACTIVATION

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 5
• Pages: 439-441

Contributors

author

M.R. Pinski

• Document Type: REVIEW
• Publication order reference: M.R. Pinski, Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA