PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2003 | 2 | 280-289
Article title

From neoplastic neural development to gene therapy of brain tumors ? IGF-I antisense and triple helix approaches

Authors
Content
Title variants
Languages of publication
EN
Abstracts
EN
IGF-I, insulin ? like growth factor I, seems to play a major role in the normal and tumoral development of the nervous system. Glioblastoma is the most frequent brain tumor in man and is usually fatal. Both human and rat glioma cells express high amounts of IGF-I. When rat glioma cells are transfected with vectors expressing either IGF-I antisense RNA or inducing IGF RNA ? DNA triple helix, the synthesis of IGF-I was stopped on translation or transcription levels, respectively. Down-regulation in the expression of IGF-I coincides with the reappearance of B-7 and MHC class I antigens at the surface of transfected cells. When injected subcutaneously, the transfected cancer cells initiate an immune reaction involving CD8+ lymphocytes, followed by tumor regression. The ?anti-gene? strategy for clinical therapy of glioblastoma, and other tumors expressing IGF-I such hepatomas were introduced in University Hospitals of Cleveland (USA), Shanghai ( China) , Krakow and Bydgoszcz (Poland).
Journal
Year
Issue
2
Pages
280-289
Physical description
References
Document Type
REVIEW
Publication order reference
J. Trojan, Katedra i Zak?ad Genoterapii, Akademia Medyczna, ul. M. Curie-Sk?odowskiej 9, 85-094 Bydgoszcz, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-245d44f4-236e-367f-b9b4-7a352d0ed7e2
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.