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2001 | 49 | 6 | 453-
Article title

Effect of IFN-on expression of HLA in bare-lymphocyte syndrome-like cell line HAJ

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EN
Abstracts
EN
We compared HLA antigen expression on new B-lymphoblastoid cell line (B-LCL) HAJ with that on B-LCLs expressing normal HLA levels as well as on B-LCLs derived from bare lymphocyte syndrome (BLS) patients and in vitro mutated B-LCLs of BLS-like phenotype. HAJ cells had no expression of HLA class II and low expression of class I antigens similarly to some of BLS B-LCLs, although HAJ cell line was derived from lymphocytes of HLA class I- and class II-normally expressing donor. HAJ cells displayed B lymphocyte markers, surface immunoglobulin and CD19. Culture of HAJ cells in the presence of interferon gamma resulted in HLA class I antigen upregulation, but did not restore class II expression. The cell line HAJ may prove useful for studies on factors influencing HLA class I cell surface expression.
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Year
Volume
49
Issue
6
Pages
453-
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author
author
author
References
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ARTICLE
Publication order reference
I. Nowak, Laboratory of Immunogenetics, Department of Clinical Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroc?aw, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-233a97d5-8afe-374f-a5fe-4dc9a56910ce
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