Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results
2001 | 49 | 6 | 453-

Article title

Effect of IFN-on expression of HLA in bare-lymphocyte syndrome-like cell line HAJ

Title variants

Languages of publication

EN

Abstracts

EN
We compared HLA antigen expression on new B-lymphoblastoid cell line (B-LCL) HAJ with that on B-LCLs expressing normal HLA levels as well as on B-LCLs derived from bare lymphocyte syndrome (BLS) patients and in vitro mutated B-LCLs of BLS-like phenotype. HAJ cells had no expression of HLA class II and low expression of class I antigens similarly to some of BLS B-LCLs, although HAJ cell line was derived from lymphocytes of HLA class I- and class II-normally expressing donor. HAJ cells displayed B lymphocyte markers, surface immunoglobulin and CD19. Culture of HAJ cells in the presence of interferon gamma resulted in HLA class I antigen upregulation, but did not restore class II expression. The cell line HAJ may prove useful for studies on factors influencing HLA class I cell surface expression.

Keywords

Contributors

author
author
author
author

References

Document Type

ARTICLE

Publication order reference

I. Nowak, Laboratory of Immunogenetics, Department of Clinical Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroc?aw, Poland

Identifiers

YADDA identifier

bwmeta1.element.element-from-psjc-233a97d5-8afe-374f-a5fe-4dc9a56910ce
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.