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2001 | 49 | 1 suppl. | 33-40
Article title

The social life of NK cells

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Languages of publication
EN
Abstracts
EN
Natural killer (NK) cells represent a distinct population of lymphocytes that was originally identified by its ability to kill transformed cell lines in vitro. It is now clear that these cells also play an important role in the innate immune response against a variety of pathogens, such as virus, bacteria and parasites. In the past few years, different protocols have been developed to activate NK cells ex vivo, allowing a detailed molecular analysis of the interaction of these cells with their cellular targets. NK activity is regulated by signals generated by both inhibitory and stimulatory receptors expressed by target cells. Indeed, recent results indicate that, while major histocompatibility complex class I molecules (MHC-I) expressed on target cells inhibit NK lytic activity by engaging surface inhibitory receptors, costimulatory molecules such as B7-1, B7-2 and CD40, are able to actively trigger NK activity. This review discusses the most recent findings on the role of costimulation on NK activation and forsees the possible consequences of the interaction between NK cells and dendritic cells (DC) on the development of an adaptive immune response.
Publisher

Year
Volume
49
Issue
Pages
33-40
Physical description
Contributors
References
Document Type
REVIEW
Publication order reference
A. Martin-Fontecha, Department of Tumor Immunology, Scientific Institute San Raffaele, Via Olgettina 58, 20132 Milano, Italy
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YADDA identifier
bwmeta1.element.element-from-psjc-232db08f-d0b1-37db-a338-6ad59476682b
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