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Number of results

Journal

2001 | 49 | 3-4 | 113-124

Article title

Contact-mediated acceleration of migration of melanoma B16 cells depends on extracellular calcium ions

Title variants

Languages of publication

EN

Abstracts

EN
The escape of malignant cells from primary tumour and their active migration to the surrounding tissues are among the most important steps in the metastatic process. During migration, tumour cells interact with neighbouring neoplastic and normal cells and such interactions may affect their motile activity. We investigated the effect of extracellular calcium ions on migration of mouse melanoma B16 cells stimulated by homotypic cell-to-cell contacts. It was found that the decreasing of extracellular Ca2+ influx into B16 cells by lowering Ca2+ concentration in culture medium, or by the application of 0.5 mM La3+ (non-selective inorganic Ca2+ channels blocker), reduced the contact-mediated acceleration of migration of melanoma cells but only slightly affected the basal motile activity of non-stimulated single, separated cells moving without contacts with neighbouring ones in sparse culture. Since it was suggested that contact-mediated acceleration of migration of melanoma B16 cells may be controlled by mechanosensitive and/or voltage-gated ion channels, the presented data support the concept that these channels may affect cell migration by regulation of extracellular Ca2+ influx into stimulated cell.

Keywords

Discipline

Journal

Year

Volume

49

Issue

3-4

Pages

113-124

Physical description

Contributors

author
author
author
author

References

Document Type

ARTICLE

Publication order reference

Z. Madeja, Department of Cell Biology, The Jan Zurzycki Institute of Molecular Biology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland

Identifiers

YADDA identifier

bwmeta1.element.element-from-psjc-21a7bb92-1d8d-30cc-8b42-ce1bdf1d6df3
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