N-terminal atrial natriuretic peptides

• Authors: J. Beltowski
• Languages of publication: PL

Abstracts

EN

Atrial myocytes synthesise atrial natriuretic factor prohormone consisting of 126 aminoacids (ANP1-126 ) which is subsequently processes to several fragments. Atrial natriuretic factor (ANF, ANP99-126) originating from the C-terminal portion of prohormone is a best described atrial peptide. However, several peptides originating from the N-terminus of this precursor also circulate and produce significant diuresis, natriuresis and vasodilatation. These are: long acting natriuretic peptide (ANP1-30), vessel dilator (ANP31-67) and kaliuretic peptide (ANP79-98). ANP1-98 and ANP68-98 also circulate. Kaliuretic peptide specifically stimulates urinary potassium excretion. These peptides are slowly metabolised and their plasma concentration is higher than ANF suggesting their important role in water-electrolyte homeostasis and regulation of vascular tone. N-terminal atrial peptides don?t bind to classical natriuretic peptide receptors, each of them has probably its own unique receptors. Although these peptides activate particulate guanylate cyclase in a number of tissues, some of their effects, for example natriuresis, are not mediated by cGMP but rather by prostaglandin E2. Plasma concentration of N-terminal atrial peptides may be useful in diagnosis and risk stratification in patients with heart failure and after myocardial infarction. Recently N-terminal fragment of brain natriuretic peptide (BNP1-76) was identified in the blood. This peptide is secreted together with its C-terminal partner, BNP77-108 by ventricular myocytes. Some studies that N-terminal BNP may be also a useful diagnostic tool in cardiovascular diseases.

Keywords

EN

ATRIAL NATRIURETIC PEPTIDE; ATRIAL PEPTIDE; KALIURETIC PEPTIDE; VESEL DILATOR

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2000
• Volume: 54
• Issue: 6
• Pages: 895-914

Contributors

author

J. Beltowski

• Document Type: ARTICLE
• Publication order reference: J. Beltowski, Katedra i Zaklad Patofizjologii AM, ul. Jaczewskiego 8, 20-090 Lublin, Poland