Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. I. Alterations of myelinated axons

• Authors: P.P. Liberski , J. Bratosiewicz-Wasik , D.C. Gajdusek , P. Brown
• Languages of publication: EN

Abstracts

EN

Classical and ultrastructural neuropathology of prion diseases are generally well described. Here we report that alterations of myelinated fibres in hamsters infected either with polioencephalopathic strains of scrapie or panencephalopathic strains of CJD (Echigo-1) are virtually identical and differ only quantitatively. In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres.

Keywords

EN

CREUTZFELDT-JAKOB DISEASE; PRION; SCRAPIE; ULTRASTRUCTURE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2002
• Volume: 62
• Issue: 3
• Pages: 121-129

Contributors

author

P.P. Liberski

author

J. Bratosiewicz-Wasik

author

D.C. Gajdusek

author

P. Brown

• Document Type: ARTICLE
• Publication order reference: P. P. Liberski, Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Biology, Chair of Oncology, Medical Academy Lodz, Poland