PL EN


Preferences help
enabled [disable] Abstract
Number of results
2004 | 52 | 4 | 215-224
Article title

Role of lipid rafts in T cells

Content
Title variants
Languages of publication
EN
Abstracts
EN
The plasma membrane of T cells is made up of a combination of phospholipids and proteins organized as glycolipoprotein microdomains termed lipid rafts. The structural assembly of lipid rafts was investigated by various physical and biochemical assays. Depending on the differentiation status of T cells, the lipid rafts seclude various protein receptors instrumental for the early T cell signaling, cytoskeleton reorganization, protein and membrane trafficking, and the entry of infectious organisms into the cells. This review article summarizes recent information on the assembly of lipid rafts in plasma membrane of T cells and their signaling output in mature and thymic precursors towards cell growth and differentiation, and possible modalities by which the function of lipid rafts can be altered by drugs and T cell ligands. The concept of using lipid rafts as a target for pharmaceutical compounds and biological T cell ligands to ultimately alter the T cell function is discussed.
Keywords
References
Document Type
REVIEW
Publication order reference
Teodor-D. Brumeanu, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
YADDA identifier
bwmeta1.element.element-from-psjc-20894b69-7dd0-3203-89ee-55d6f08691fe
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.