Developmental expression of major myelin proteins in hypomyelinated pt mutant rabbit

• Authors: Joanna Sypecka , Mirjana Tosic , Michel Dolivo , Krystyna Domanska-Janik , Jean-Marie Mathieu
• Languages of publication: EN

Abstracts

EN

A term "paralytic tremor" (pt) is attributed to a neurological mutation of Chinchilla rabbits, affecting the evelopment of the central nervous system (CNS). A quantification of myelin protein content indicates the strong CNS hypomyelination during the development (1-120 postnatal days). SDS-PAGE electrophoresis of total brain homogenates, followed by immunoblotting, shows a reduced concentration of major myelin-connected proteins. MBP deficiency coressponds approximately to the level of the hypomyelination, whereas PLP expression is drastically reduced.

Keywords

EN

CNS HYPOMYELINATION; MYELIN PROTEIN; RABBIT MUTANT

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1993
• Volume: 53
• Issue: 1
• Pages: 281-284

Contributors

author

Joanna Sypecka

author

Mirjana Tosic

author

Michel Dolivo

author

Krystyna Domanska-Janik

author

Jean-Marie Mathieu

• Document Type: paper