Developmental expression of major myelin proteins in hypomyelinated pt mutant rabbit
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A term "paralytic tremor" (pt) is attributed to a neurological mutation of Chinchilla rabbits, affecting the evelopment of the central nervous system (CNS). A quantification of myelin protein content indicates the strong CNS hypomyelination during the development (1-120 postnatal days). SDS-PAGE electrophoresis of total brain homogenates, followed by immunoblotting, shows a reduced concentration of major myelin-connected proteins. MBP deficiency coressponds approximately to the level of the hypomyelination, whereas PLP expression is drastically reduced.
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