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1995 | 49 | 5 | 585-597
Article title

The role HTLV-I in the T lymphocytes transformation

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PL
Abstracts
EN
HTLV-I virus is as etiological agent of adult T-cell leukemia (ATL).The virus encodes Tax regulatory protein, which induces malignant transformation of the T lymphocytes.Tax increases the expression of cell protooncogenes as well as lymphokines, among others IL-2 and its receptor.This protein induces autocrine proliferation of T lymphocytes, which is probably the main cause of their transformatn.Tax represses the human beta-polymerase gene enzyme involved in host cell DNA repair, and then inversible damage is effected in the T lymphocyte genome.Moreover, this regulatory protein cooperates with Rex phosphoprotein, stabilizing cell mRNA, which originate as the result of Tax protein activity.The regulatory proteins of HTLV-I virus influence the transcription of some genes their products and this way induce malignant transformation.
Year
Volume
49
Issue
5
Pages
585-597
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author
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Document Type
article
Publication order reference
M.Papiez
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YADDA identifier
bwmeta1.element.element-from-psjc-1ddd9c38-b87a-3cd7-834c-abb15a221bb1
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