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1997 | 57 | 1 | 71-74
Article title

Naloxone impairs spatial performance in rats

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Abstracts
EN
Naloxone injected (1.0 mg/kg) and saline injected control rats were subjected to a two trial test of object localization memory. In trial I rats were allowed to explore for 5 min an enclosed T maze with an object (plastic bottle) placed in one maze arm. Then, the object was removed and after a 20 min retention interval rats were faced with two empty arms of the same maze (trial II). Control rats showed good retention of the place occupied by the object, displaying a significant preference (74%, ) for the arm which previously contained the object. Naloxone treated rats responded at chance levels (53%). An accurate performance in this task is normally based on information provided by spatial cues outside the maze (cognitive map), so that a random performance of Naloxone treated rats could supposedly be related to some disorders in the internal representation of the environment.
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Year
Volume
57
Issue
1
Pages
71-74
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Document Type
short communica
Publication order reference
I.Lukaszewska, Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-1b6c7834-6248-390f-aecb-44a9b088ab89
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