PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 49 | 1 | 75-79
Article title

Allelic variation of the porcine -1,3-galactosyltransferase 1 (GGTA1) gene

Authors
Title variants
Languages of publication
EN
Abstracts
EN
The alpha-1,3-galactosyltransferase 1 enzyme (GGTA1) produces the -Gal epitopes, responsible for pig-to-human hyperacute xenograft rejection. Recently, efforts have been directed at inactivating the porcine GGTA1 gene in order to reduce hyperacute rejection. As very little is known about the genetic variability of this key gene among pig breeds, we investigated the variation in its nucleotide sequence, by amplification of the entire coding region with the use of polymerase chain reaction followed by DNA sequencing. Eight commercial pig populations were analysed and 17 single nucleotide polymorphisms (SNPs) were detected: 11 in intronic regions and 6 in the 3' untranslated region (UTR). No SNPs change the encoded protein; however, 8 of these SNPs may alter the transcriptional regulation and pre-mRNA splicing of GGTA1.
Discipline
Publisher

Year
Volume
49
Issue
1
Pages
75-79
Physical description
Contributors
author
author
References
Document Type
ARTICLE
Publication order reference
D. Rocha, UMR1061, INRA ? Universite de Limoges, Faculte des Sciences, 123 Avenue Albert Thomas, 87060 Limoges, France
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-1b5932d0-9416-38ce-aa05-6d34473ee4c0
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.