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1996 | 56 | 1 | 49-554

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The contribution of AT1 and AT2 angiotensin receptors to its cognitive effects


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In this study I attempted to assess, in rats, the role of AT(1) and AT(2) angiotensin receptor subtypes in the phenomenon of improved learning and memory after an intracerebroventricular (icv) injection of angiotensin II (Ang II) and Ang II (3-7). Selective AT(1) (losartan, 1mg) or AT(2) (CGP 42112 A, 2 mugg) receptor antagonist was dissolved in 2 mugl of saline and given to the left cerebral ventricle 5 min before 1nmol Ang II or Ang II (3-7) injected in the same volume of saline to the right ventricle. Consequently, there were 9 experimental groups which underwent 3 memory oriented and 3 auxiliary tests. Ang II and Ang II (3-7) significantly improved retention of passive avoidance and recognition memory. These effects were abolished by losartan or CPG 42112 A.Better, after Ang II And Ang II (3-7), acquisition of conditioned avoidance responses was unchanged by losartan and abolished by CGP 42112 A. None of the treatments significantly changed rats motor behaviour in open field. Losartan as well as CGP 42112 A abolished significant enhancement of apomorphine (1 mg/kg, ip) stereotypy caused by Ang II and Ang II (3-7). The results suggest considerable involvement of AT(1) and AT(2) angiotensin receptors in the cognitive enhancement produced by angiotensins.





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