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2000 | 48 | 4 | 259-266
Article title

Role of immune-derived diffusible mediators in AIDS-associated neurological disorders

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EN
Abstracts
EN
Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
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Document Type
REVIEW
Publication order reference
F. Ensoli, Department of Allergy and Clinical Immunology, University of Rome, La Sapienza, 00185 Rome, Italy
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YADDA identifier
bwmeta1.element.element-from-psjc-195a9dee-93b5-3019-911e-b8a9ed80ca75
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