Regulation of IL-5 expression

• Authors: V.A. Mordvinov , C.J. Sanderson
• Languages of publication: EN

Abstracts

EN

Interleukin-5 (IL-5) is a cytokine primarily involved in the pathogenesis of atopic diseases. It specifically controls the production, activation and localization of eosinophils, the major cause of tissue damage in atopic diseases. IL-5 belongs to a gene family shared by IL-3, IL-4 and GM-CSF and is predominantly regulated at the transcriptional level. A variety of stimuli and modulators have been identified as regulating production of IL-5 both in vivo and in vitro, indicating a highly complex series of control mechanisms. However, a better understanding of the biology of IL-5 and the regulation of its expression is crucial for the development of new therapeutic agents for allergic disease. This review covers the major molecular aspects of IL-5 research.

Keywords

EN

ALLERGIC DISEASE; CYTOKINE; INTERLEUKIN 5

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 5
• Pages: 345-352

Contributors

author

V.A. Mordvinov

author

C.J. Sanderson

• Document Type: REVIEW
• Publication order reference: V.A. Mordvinov, Curtin University of Technology, Perth, Western Australia