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2001 | 49 | 5 | 345-352
Article title

Regulation of IL-5 expression

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EN
Abstracts
EN
Interleukin-5 (IL-5) is a cytokine primarily involved in the pathogenesis of atopic diseases. It specifically controls the production, activation and localization of eosinophils, the major cause of tissue damage in atopic diseases. IL-5 belongs to a gene family shared by IL-3, IL-4 and GM-CSF and is predominantly regulated at the transcriptional level. A variety of stimuli and modulators have been identified as regulating production of IL-5 both in vivo and in vitro, indicating a highly complex series of control mechanisms. However, a better understanding of the biology of IL-5 and the regulation of its expression is crucial for the development of new therapeutic agents for allergic disease. This review covers the major molecular aspects of IL-5 research.
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Document Type
REVIEW
Publication order reference
V.A. Mordvinov, Curtin University of Technology, Perth, Western Australia
YADDA identifier
bwmeta1.element.element-from-psjc-19367b96-1641-36a5-bde4-b7b731be7e69
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