Antisense oligonucleotides to PAI-1 mRNA as potential agents for therapeutic intervention in cardiovascular diseases

• Authors: C.S. Cierniewski , Z. Pawlowska , E. Pluskota , M. Stasiak , A. Kobylanska , K. Misiura , A. Maciaszek , M. Koziolkiewicz , W. J. Stec
• Languages of publication: EN

Abstracts

EN

In this report we discuss the possibility of using antisense oligonucleotides specific to PAI-1 mRNA to reversibly decrease PAI-1 level in blood plasma and thus prolong a half-life time endogenous plasminogen activators in circulation.

Keywords

EN

ANTISENSE OLIGONUCLEOTIDE; CARDIOVASCULAR DISEASE; PEPTIDE ANALOGUE; RECOMBINANT PROTEIN

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 1996
• Issue: 4
• Pages: 141-152

Contributors

author

C.S. Cierniewski

author

Z. Pawlowska

author

E. Pluskota

author

M. Stasiak

author

A. Kobylanska

author

K. Misiura

author

A. Maciaszek

author

M. Koziolkiewicz

author

W. J. Stec

• Document Type: article
• Publication order reference: C.S.Cierniewski, Dept. of Biophysics, Medical University in Lodz, Lindleya St. 3, 91-131 Lodz, Poland