The effect of calcium channel blockade on the action of chronic ECT and imipramine on responses of alpha-1 and beta-adrenoceptors in the rat cerebral cortex

• Authors: Irena Nalepa , Jerzy Vetulani
• Languages of publication: EN

Abstracts

EN

Chronic co-administration of nifedipine and ECT or imipramine results in an increase in responsiveness of cerebral cortical alfa1-adrenoceptor as measured by accumulation of inositol phosphate in cortical slices after noradrenaline stimulation; the responsiveness of beta-adrenoceptor, measured by accumulation of cyclic AMP, was depressed similarly by antidepressant treatment with and without nifedipine.

Keywords

EN

ALPHA1-ADRENOCEPTOR; BETA-ADRENOCEPTOR; CYCLIC AMP; IMIPRAMINE; INOSITOL PHOSPHATE; NIFEDIPINE

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 2
• Pages: 201-205

Contributors

author

Irena Nalepa

author

Jerzy Vetulani

• Document Type: communication