The article reviews the development of molecular investigations of the genus Mycobacterium. Achievements and difficulties of the genetics of mycobacteria are presented. Vectors and selectable markers commonly used in genetic manipulations and methods of introduction of foreign DNA into mycobacteria are described. The stress is laid not only on the research of the virulent mycobacteria, but also on molecular investigations of the non-pathogenic strains used in steroid drugs industry.
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E. Golanska, Samodzielna Pracownia Biosyntezy Srodkow Leczniczych, Akademia Medyczna, ul. Muszynskiego 1, 90-145 Lodz, Poland