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2001 | 55 | 1 | 133-156
Article title

New collagenous proteins: FACITs, transmembrane collagens and multiplexins

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Languages of publication
PL
Abstracts
EN
Collagens are the main components of the extracellular matrix and they constitute about 30% of total body protein. Each collagen molecule consists of three polypeptide chains that intertwine in one or more places into triple helical domains, a very rare structure in other proteins. Nineteen collagen types have been described to date and those forming banded fibrils are the most abundant. In the last decade new collagenous proteins were discovered that have been classified into three distinct groups: fibril-associated collagens with interrupted triple helices (FACITs), transmembrane collagens and multiplexins. FACITs appear to connect collagen fibrils to other matrix components or cells. Transmembrane collagens have intracellular domains and they participate in cell adhesion and probably in signal transduction. Multiplexins are situated mainly in basement membranes and contain sequences, which demonstrate features of angiogenesis inhibitors reducing the growth of neoplasmatic tumours.
Publisher

Year
Volume
55
Issue
1
Pages
133-156
Physical description
Contributors
author
author
References
Document Type
ARTICLE
Publication order reference
Tomasz Gogiel, Zaklad Biochemii AM, ul. Mickiewicza 2, 15-230 Bialystok, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-112f3f61-2ee2-390a-84e6-ee07e3030a81
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