Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl


Preferences help
enabled [disable] Abstract
Number of results


2002 | 50 | 1-2 | 53-56

Article title

Gene polymorphisms of the renin-angiotensin-aldosterone system and essential arterial hypertension in childhood

Title variants

Languages of publication



In order to investigate the contribution of candidate genes in the renin-angiotensin- -aldosterone system (RAAS) in pathogenesis of essential arterial hypertension (EAH), the I/D polymorphism of ACE gene, the M235T polymorphism of the angiotensinogen gene, and the angiotensin II type 1 receptor (AGT1R) A1166C gene polymorphism in a group of children with EAH were analyzed. Fifty-seven children, aged 8-19 years, with the diagnosis of EAH were included in the association study and were compared with 57 subjects with normal blood pressure (the control group). Arterial hypertension was defined as systolic/diastolic blood pressure measurements higher than 95 age-gender-height percentile of the adopted reference values. A trend was found towards an association between the M235T angiotensinogen gene polymorphism and EAH in childhood in a dominant model (odds ratio (OR) 2.1; 95 % confidence interval (CI) 0.9-5.1; P=0.077), whereas the authors failed to demonstrate an association between the ACE I/D gene polymorphism, or the A1166C AGT1R gene polymorphism and EAH in childhood. Additionally, evidence was found of interaction between the angiotensinogen-TT genotype and obesity on the risk of EAH in childhood (OR 19.3; 95% CI 1.1-77.3; P=0.014). In conclusion, the M235T angiotensinogen gene polymorphism is considered alone as well as in interaction with obesity to be risk factors for EAH in childhood.




Document Type


Publication order reference

D. Petrovic, Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Korytkova 2, 1105 Ljubljana, Slovenia


YADDA identifier

JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.