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2002 | 56 | 4 | 461-483
Article title

Molecular characterization of the monoclonal antibodies recognizing human glycophorin A

Authors
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Languages of publication
PL
Abstracts
EN
Glycophorin A, the major sialoglycoprotein of human erythrocytes and carrier of MN blood group antigens, is a good model to study immune response against glycopeptide antigens. Molecular analysis of several monoclonal antibodies recognizing GPA revealed that the immune response against N, but not M, antigen is restricted. It was shown that the recombinant Fab fragments expressed in the phage display system may provide novel reagents with application in immunohematology. The new recombinant Fab fragments revealed increased affinity toward GPA. Introduction of dimer-inducing peptides causes creation of bivalent Fab fragments revealing increased avidity.
Publisher

Year
Volume
56
Issue
4
Pages
461-483
Physical description
Contributors
author
References
Document Type
ARTICLE
Publication order reference
M. Czerwinski, Instytut Immunologii i Terapii Doswiadczalnej PAN, ul. Weigla 12, 53-114 Wroclaw, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-0fd1566a-8545-3515-b2ce-fc7749fe68e4
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