PL EN


Preferences help
enabled [disable] Abstract
Number of results
2004 | 52 | 6 | 427-431
Article title

Recent controversy surrounding lipid rafts

Authors
Content
Title variants
Languages of publication
EN
Abstracts
EN
Lipid rafts (LRs) are highly enriched in glycosphingolipids, sphingomyelins, and cholesterol membrane microdomains, existing in a liquid-ordered phase of the plasma membrane. In the literature, LRs are also known as detergent-insoluble membranes, detergent- resistant membranes, glycosphingolipids-enriched membranes, detergent-insoluble glycolipid-rich membranes, and Triton-insoluble floating fractions. These properties enabled their separation from the rest of the phospholipid bilayer, providing new insight into the structure of the plasma membrane, which until then was believed to represent a two-dimensional liquid structure with proteins uniformly solubilized in the lipid solvent. Although there have been many articles concerning LRs, there is still controversy about their existence in the natural state, their size, definition, and function. Different techniques have been developed to visualize LRs in living cells, but the results are contradictory. In this minireview, some recent papers concerning LRs, their existence in vivo, their dynamics, size, methods of isolation, and their association with different proteins are discussed.
Keywords
EN
References
Document Type
REVIEW
Publication order reference
Martyna Skwarek, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-0db75ecc-071a-3869-b644-314c1420d0af
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.