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1993 | 47 | 3 | 183-191
Article title

<Mitotic cyclins> - a new way of research on <cancer> mechanisms

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Languages of publication
PL
Abstracts
EN
<Mitotic cyclins> constitute a regulatory subunit of the <histone H1 kinase> complex. On the ground of their primary structure they are divided into two classes A and B, both necessary for the <mitosis>. <Cyclin A> activates histone H1 kinase and becomes destroyed by <proteolysis> earlier than <cyclines B> and plays an important role in the <DNA replication>. <Cyclins> A and B may be involvent in the development of <neoplastic disorders> either directly inappropriate expression of the cyclin A gene caused by hepatitis B virus in hepatocellular carcinoma, or interactions of this cyclin with factors paricipating in the regulation of cell proliferation or indirectly by phosphorylation of some oncogene or antioncogene proteins by a cdk (cyclin dependent kinase).
Publisher

Year
Volume
47
Issue
3
Pages
183-191
Physical description
Contributors
References
Document Type
article
Publication order reference
Dariusz Wolowiec
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-0cb058c2-7f36-3283-81b1-5bcf1b697262
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