<Mitotic cyclins> - a new way of research on <cancer> mechanisms

• Authors: Dariusz Wolowiec , Martine Ffrench
• Languages of publication: PL

Abstracts

EN

<Mitotic cyclins> constitute a regulatory subunit of the <histone H1 kinase> complex. On the ground of their primary structure they are divided into two classes A and B, both necessary for the <mitosis>. <Cyclin A> activates histone H1 kinase and becomes destroyed by <proteolysis> earlier than <cyclines B> and plays an important role in the <DNA replication>. <Cyclins> A and B may be involvent in the development of <neoplastic disorders> either directly inappropriate expression of the cyclin A gene caused by hepatitis B virus in hepatocellular carcinoma, or interactions of this cyclin with factors paricipating in the regulation of cell proliferation or indirectly by phosphorylation of some oncogene or antioncogene proteins by a cdk (cyclin dependent kinase).

Keywords

EN

DNA REPLICATION; HISTONE H1 KINASE; MITOTIC CYCLIN; TUMOR DEVELOPMENT

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1993
• Volume: 47
• Issue: 3
• Pages: 183-191

Contributors

author

Dariusz Wolowiec

author

Martine Ffrench

• Document Type: article
• Publication order reference: Dariusz Wolowiec