PL EN


Preferences help
enabled [disable] Abstract
Number of results
2001 | 61 | 4 | 277-287
Article title

Changes in short-term potentiation of hypoglossal activity by modulators of nitric oxide production in the rabbit

Content
Title variants
Languages of publication
EN
Abstracts
EN
Stimulation of the superior laryngeal nerve (SLN) causes a potentiation of hypoglossal nerve activity persisting after cessation of stimulation. The mechanism of this phenomenon is uncertain. We investigated a potential role of the nitric oxide (NO) pathway in modulation of the after-effects of SLN stimulation on phrenic and hypoglossal activity in rabbits. L-Arginine, a substrate for NO synthesis and NG-Nitro-L-Arginine (L-NNA) an inhibitor of NO synthase (NOS), were administered systemically. L-Arginine and L-NNA alone caused small changes in respiratory activity. During pre-treatment with NO precursor the amplitude and duration of hypoglossal potentiation evoked by SLN stimulation were reduced. Systemic NO synthase inhibition partially reversed these effects of L-Arginine. The results showed that interference with NO production by NO substrate and NOS inhibitor modulates the effects of SLN stimulation on hypoglossal activity. Nitric oxide might be a negative modulator of the transmission of short-term potentiation (STP) in hypoglossal activity.
References
Document Type
ARTICLE
Publication order reference
K. Budzinska, Department of Neurophysiology, Medical Research Centre, Polish Academy of Sciences, 5 Pawinski St., 02-106 Warsaw, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-0c2771ed-eb97-3c1f-a2f8-7adcb456d76c
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.